A novel biologic therapeutic platform designed to enable advanced tumor-specific targeting and payload delivery through engineered, multi-specific logic control.
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THE SYNTHBODYTM PLATFORM
SYNTHBODYTM
This multifunctional, multivalent, multispecific biologic platform optimizes payload delivery to highly specific target cells, coordinates conditional biologic signals, and combines multi pathway activity, unlocking ADC treatment possibilities beyond what natural biology allows.
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SYNTHETIC TARGETS
Rather than targeting isolated proteins or even two different proteins, SYNTHBODY™ detects combinations of proteins on cancer cell surfaces, both proximal and distant, in a coordinated and logic-gated fashion. This creates a “synthetic target” that unlocks a potential log-order increase in ADC potency, specificity of targeting, multifunctionality, and logic control.
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MULTIFUNCTIONAL MULTIVALENT MULTISPECIFICS
Scale Matters. With more active interaction sites than other therapeutics, multifunctionality is no longer a tradeoff - it’s integrated with multispecific targeting components in a directed, logical fashion.
This enables the coordination of multiple biologic targets and pathways. We’re advancing therapeutics through precision engineering, in which multiple targets and pathways work together under multilayered logic control tailored to specific indications and human biology.
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MULTILAYERED LOGIC CONTROL
SYNTHBODY™ goes further with BIO-LOGIC™ control. Most bi-specific therapeutics utilize simple “AND” gates to enhance safety. SYNTHBODY BIO-LOGIC™ harnesses multi-layer logic control that incorporates “AND-BETTER”, “OR”, “AND”, “MULTIPLIERS” as well as spatial, temporal and conditional cues.
Like transistors, SYNTHBODY BIO-LOGIC™ product candidates are designed with multi-layer logic controls that allow them to adjust to different inputs that are defined by a given cancer cell, tumor environment, and/or physiologic state.
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